Evidence map›Paper›PMID 41387453›Full record

ArticleNPJ vaccines2025

Protective immunity induced by Tp0136 epitope vaccines with mRNA LNP or protein delivery.

Yinbo Jiang, Nanxuan Huang, Lixia Huang, Xinyuan Li, Xiangcai Zhang, Gang Zheng, Tayier Tuerhong, Han Liu, Jiaxi Lai, Chunmei Liang and 6 more

Abstract read
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yinbo Jiang *Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Nanxuan Huang *Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Lixia Huang *Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xinyuan Li *Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiangcai ZhangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Gang ZhengThe First People's Hospital of Kashi, Kashi, Xinjiang, China.
Tayier TuerhongThe First People's Hospital of Kashi, Kashi, Xinjiang, China.
Han LiuDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiaxi LaiDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Chunmei LiangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiaohui ZhangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Liuyuan WangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Rongyi ChenDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China. rongyichen@163.com.
Cailing AoMonitoring Section, Guangzhou Baiyun District Center for Disease Control and Prevention, Guangzhou, Guangdong, China. 1908118543@qq.com.
Bin YangDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China. yangbin1@smu.edu.cn.
Wujian KeDermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China. kewujian@pumcderm.cams.cn.

Funding

Basic Research Incubation Project of Dermatology Hospital, Southern Medical University BR202406Basic Research Incubation Project of Dermatology Hospital, Southern Medical University BR202409CAMS Innovation Fund for Medical Sciences 2025-I2M-C&T-B-081European Research Council Consolidator Grant (Horizon Europe Program) 101171779Hospital-level Project of The First People's Hospital of Kashi KDYY202002National Natural Science Foundation of China 82072321Natural Science Foundation of Guangdong Province 2025A1515011165Zhujiang Scholar · Tianshan Talent Program KDYY202023
6 · The paper itself

Abstract

Syphilis, caused by Treponema pallidum, remains a major global health burden. Given the key role of T cell-mediated immunity in T. pallidum clearance, this study evaluates a Tp0136-derived T-cell epitope (Tp0136

Identifiers

PMID41387453
PMCPMC12808113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.