Evidence map›Paper›PMID 41387419›Full record

ArticleNature communications2025

The long non-coding RNA UGDH-AS1 encodes an NK-cell-inhibiting micropeptide in triple-negative breast cancers.

Zheng Zhang, Fanrong Li, Xiaoxiao Dai, Jieqiong Deng, Binbin Guo, Yirong Wang, Wei Liu, Yacheng Pan, Tong Zhao, Shuang Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zheng Zhang *Jiangsu Clinical Medicine Research Institute, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Fanrong Li *Department of Genetics, Medical College of Soochow University, Suzhou, China.
Xiaoxiao Dai *Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jieqiong DengDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Binbin GuoDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Yirong WangDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Wei LiuDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Yacheng PanDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Tong ZhaoDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Shuang WangDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Wanqiu LiDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Congnan JinDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Hebin ZhangDepartment of Genetics, Medical College of Soochow University, Suzhou, China.
Shenghua ZhangJiangsu Clinical Medicine Research Institute, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 15707974247@163.com.ORCID http://orcid.org/0000-0001-6247-9078
Yifeng ZhouJiangsu Clinical Medicine Research Institute, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. zhouyifeng@njmu.edu.cn.ORCID http://orcid.org/0000-0003-1847-7985

Funding

China National Funds for Distinguished Young Scientists 82125027National Science Foundation of China | Key Programme 2022YFA1305500National Science Foundation of China | Young Scientists Fund 82303096National Science Foundation of China | Young Scientists Fund 82303232
6 · The paper itself

Abstract

NK cells are important for the anti-tumour immune response for their potential to kill MHC class I-deficient tumor cells, but they often become dysfunctional in the immune-hostile tumour microenvironment. Here, using single-cell RNA sequencing, we identify an NK cell subpopulation that is specific to triple-negative breast cancers (TNBC) subtype, characterised by the expression of the long non-coding RNA UGDH-AS1. In these NK cells, UGDH-AS1 encodes the micropeptide, NKSM, which renders these NK cells dysfunctional due to the loss of their activation program, which leads to cancer progression. Conditional NKSM knock-in into NK cells of mice results in NK cell deactivation and increased growth of transplanted tumours. Targeted NKSM therapy effectively reduces tumor growth in TNBC mouse models. We find that UGDH-AS1

Indexed as

Killer Cells, NaturalPeptidesRNA, Long NoncodingTriple Negative Breast NeoplasmsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMiceProto-Oncogene Proteins c-mycTransforming Growth Factor betaTumor MicroenvironmentPeptidesProto-Oncogene Proteins c-mycRNA, Long NoncodingTransforming Growth Factor beta

Identifiers

PMID41387419
PMCPMC12749931

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.