Evidence map›Paper›PMID 41387356›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Cross-Platform Biosensing of Immune Receptors Using Peptide-Functionalized Graphene.

Ahmar Hasnain, Heiko Heilmann, Annabel Pohl, Celine Weber, Bernd Bufe, Alexey Tarasov

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmar HasnainNanoelectronics & Biosensing Lab, Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr. 1, 66482, Zweibrücken, Germany.
Heiko HeilmannMolecular Immunology Lab, Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr. 1, 66482, Zweibrücken, Germany.
Annabel PohlNanoelectronics & Biosensing Lab, Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr. 1, 66482, Zweibrücken, Germany.
Celine WeberMolecular Immunology Lab, Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr. 1, 66482, Zweibrücken, Germany.
Bernd BufeMolecular Immunology Lab, Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr. 1, 66482, Zweibrücken, Germany.
Alexey TarasovNanoelectronics & Biosensing Lab, Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr. 1, 66482, Zweibrücken, Germany.ORCID https://orcid.org/0009-0007-9109-619X

Funding

Deutsche Forschungsgemeinschaft (DFG) 520334485European Union 101119473German Federal Ministry of Research, Technology and Space (BMFTR) 13FH521KX9German Federal Ministry of Research, Technology and Space (BMFTR) 13FH579KX2Ministry of Science and Health of Rhineland-Palatinate MultiSensE
6 · The paper itself

Abstract

Changes in the composition of specific cell-surface molecules on immune cells are important early markers of directed immune responses. Current biosensors largely focus on detecting soluble disease markers. Here, a peptide-functionalized graphene biosensor is presented capable of platform-independent, highly sensitive detection of specific immune receptors on living cells. Formyl peptide receptor 2 (FPR2) is targeted, a key modulator of innate immune cells, and validated the technology in two complementary formats: i) graphene-enhanced surface plasmon resonance (SPR) as a robust optical benchmark, and ii) graphene field-effect transistors (gFETs) as a compact, cost-effective electrical alternative. Target specificity is first confirmed using HEK293T cells selectively overexpressing FPR2. Detection of FPR2 on primary human neutrophils is achieved with high reproducibility using fewer than 10 000 cells mL

Indexed as

Biosensing TechniquesGraphitePeptidesReceptors, Formyl PeptideReceptors, ImmunologicHEK293 CellsHumansNeutrophilsSurface Plasmon ResonanceGraphitePeptidesReceptors, Formyl PeptideReceptors, Immunologicbiosensinggraphene field‐effect transistor (gFET)immune receptorspeptide‐functionalized graphenesurface plasmon resonance (SPR)

Identifiers

PMID41387356
PMCPMC13042608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.