Evidence map›Paper›PMID 41387226›Full record

ArticleAnnals of clinical and translational neurology2026

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage.

Yasmin N Aziz, Carl D Langefeld, Mary E Comeau, Miranda C Marion, Tyler P Behymer, Lee A Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J Williamson and 16 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yasmin N AzizDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-3515-4005
Carl D LangefeldDepartment of Biostatistics and Data Science, Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Mary E ComeauDepartment of Biostatistics and Data Science, Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Miranda C MarionDepartment of Biostatistics and Data Science, Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Tyler P BehymerDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Lee A GilkersonDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Padmini SekarDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Weihong YuanDivision of Radiology, Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Vivek KhandwalaDepartment of Radiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Brady J WilliamsonDepartment of Radiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Thomas MaloneyDepartment of Radiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Achala VagalDepartment of Radiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Pierce BoyneDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Kari DunningDepartment of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Matthew L FlahertyDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Steven J KittnerDepartment of Neurology, University of Maryland, Baltimore, Maryland, USA.
Prachi MehndirattaDepartment of Neurology, University of Maryland, Baltimore, Maryland, USA.
Gunjan Y ParikhDepartment of Neurology, University of Maryland, Baltimore, Maryland, USA.
Michael L JamesDepartment of Anesthesiology, Duke University, Durham, North Carolina, USA.
David RohDepartment of Neurology, Columbia University, New York, New York, USA.ORCID 0000-0003-1927-7686
Fernando D TestaiDepartment of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, Illinois, USA.
Farhaan S VahidyHouston Methodist Academic Institute, Houston Methodist, Houston, Texas, USA.ORCID 0000-0002-3464-2111
James ThorntonDepartment of Neurology, Baptist Health Louisville, Louisville, Kentucky, USA.
Ranjit BaggaDepartment of Radiology, Baptist Health Louisville, Louisville, Kentucky, USA.
Daniel WooDepartment of Neurology, University at Buffalo, Buffalo, New York, USA.
Stacie L DemelDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Funding

Genetic and Environmental Risk Factors for Hemorrhagic Stroke – VRF1NS036695 · NINDS · UNIVERSITY OF CINCINNATI · PI DEMEL, STACIE, LANGEFELD, CARL D · 2024 to 2024
$2.4M
Institute for Clinical & Translational ResearchNational Center for Advancing Translational Sciences Clinical Translational Science Award 1UL1TR003098NINDS NIH HHS 2RF1NS036695-20NINDS NIH HHS RF1 NS036695The Wake Forest UniversityUniversity of Maryland, Baltimore
6 · The paper itself

Abstract

backgroundAmbulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi- and contra-lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post-ICH ambulation.

methodsPatients with spontaneous supratentorial ICH were recruited from 8 US sites between 2017 and 2024. For each patient, fractional anisotropy (FA) asymmetry index (AI) was computed for the whole CST and on a subset of fibers restricted to the cerebral peduncle (CP). Clinical and radiographic features were collected. The primary outcome was Barthel Index Mobility Score (BIMS) at 3 months (dichotomized outcome [DO]: BIMS 15 = good [independent ambulation]; BIMS < 15 = poor [non-independent ambulation]; ordinal outcome [OO]: BIMS 0, 5, 10, 15). Two imputation-based multiple logistic regression analyses accounted for whether ICH prevented tracking of CSTs. Odds ratios (ORs) were reported for a change of 0.1 and 95% confidence intervals (CIs).

resultsAt 3 months, 124 patients were eligible for inclusion. In addition to known clinical variables, CST and CP FA AI were associated with poor BIMS (OR 2.97, CI 1.12-7.90, p = 0.029; OR 3.80, CI 1.63-8.84, p = 0.002). In Model 1, unresolved FA (FA zero) was not correlated with lower BIMS (DO: OR 3.25, CI 0.62-17.07, p = 0.163; ordinal outcomes: OR 2.02, CI 0.48-8.55, p = 0.341). In Model 2, the combination of CST FA AI and FA zero correlated with lower BIMS (DO: joint p-value =0.041; OO: p = 0.030). CP FA asymmetry was associated with lower BIMS (DO: OR 3.96, CI 1.25-12.55, p = 0.019; OO: OR 3.39, CI 1.24-9.27, p = 0.017).

conclusionDTI-assessed CST integrity may be an additional tool physicians can utilize to guide post-ICH ambulatory expectations.

Indexed as

Cerebral HemorrhagePyramidal TractsWalkingAgedCerebral PeduncleDiffusion Tensor ImagingFemaleHumansMaleMiddle Ageddiffusion tensor imaginghemorrhagemobility

Identifiers

PMID41387226
PMCPMC13161879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.