Evidence map›Paper›PMID 41386891›Full record

ArticleJournal, genetic engineering & biotechnology2025

Silver nanoparticles synthesised using endophytic fungus Calonectria eucalypti from medicinal plant axifraga stolonifera and their bioactivity.

Tianyu Lv, Meiqi Chen, Xixian Li, Yu Long, Yiwen Liang, Tingting Jiang, Jiayi Chen, Yichao Huang, Kailing Guo, Yi Cheng and 2 more

Abstract read
In one paragraph

Article in Journal, genetic engineering & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianyu LvSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Meiqi ChenDongguan University of Technology, Dongguan 523808, PR China.
Xixian LiSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Yu LongSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Yiwen LiangSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Tingting JiangSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Jiayi ChenSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Yichao HuangSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Kailing GuoSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Yi ChengSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
Zujun DengSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address: dengzujun66@163.com.
Zhuoya WangSchool of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address: wangzhuoya@gdpu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver nanoparticles (AgNPs) are widely used but traditional synthesis methods are energy-intensive and polluting. Biosynthesis offers an eco-friendly approach, yet studies on medicinal plant endophytic fungi remain scarce. This work reports the isolation and characterization of AgNPs synthesized by endophytic fungi from Saxifraga stolonifera, along with an assessment of their bioactivities, including antimicrobial, anticancer, and antioxidant effects. AgNPs were biosynthesized using the aqueous extract of the fungus HECL10, which was identified as Calonectria eucalypti. The HECL10-AgNPs were characterised by UV‒vis spectroscopy, SEM, EDS, TEM, FT-IR and zeta potential analysis. The drug susceptibility experiments illustrated that HECL10-AgNPs exhibited potent antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Additionally, the cytotoxicity assays revealed that the HECL10-AgNPs exhibited prominent anticancer effects on the A549, A375, HeLa and HepG2 cell lines. Notably, the scavenging rates of HECL10-AgNPs at 200 µg/mL against DPPH, ABTS, and OH radicals were 90.49 %, 60.38 %, and 38.76 %, respectively. Compared to the H

Indexed as

BioactivityBiosynthesisEndophytic fungiMedicinal plantSilver nanoparticles

Identifiers

PMID41386891
PMCPMC12718144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.