Evidence map›Paper›PMID 41386854›Full record

ArticleJournal, genetic engineering & biotechnology2025

STAT4 gene polymorphism promotes progression of rheumatoid arthritis.

Dawood Ali Salim Dawood, Anwar Madlool Al-Janabi, Rana Talib Al-Muswie, Lee Suan Chua, U A Al-Sari, Samer Alwazni

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Article in Journal, genetic engineering & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Dawood Ali Salim DawoodDepartment of Pathology and Forensic Medicine, College of Medicine, Wasit University, Kut 52001, Iraq. Electronic address: alisalim@uowasit.edu.iq.
Anwar Madlool Al-JanabiDepartment of Biochemistry, College of Medicine, Kufa University, Kufa 54002, Iraq.
Rana Talib Al-MuswieDepartment of Basic Sciences, College of Dentistry, University of Thi-Qar, Thi-Qar 64001, Iraq.
Lee Suan ChuaInstitute of Bioproduct Development, Universiti Teknologi Malaysia, Skudai, Johor Bahru 81310 Johor, Malaysia; Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, UTM Skudai, Johor Bahru 81310 Johor, Malaysia.
U A Al-SariDepartment of Medicine, College of Medicine, Wasit University, Kut 52001, Iraq.
Samer AlwazniDepartment of Surgery, College of Medicine, Wasit University, Kut 52001, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid Arthritis (RA) is a chronic autoimmune disease. Right now, different genes play a crucial role in disease development. The objective was to assess the correlation between STAT4 gene polymorphism (SNPs: rs11889341, rs10181656 and rs7574865) and susceptibility to RA progression in Iraqi population.

methodsThree Hundred Twenty-five RA patients and Three Hundred Twenty-five matched controls were enrolled in this study. The genotyping for SNPs was performed using (Tetra-ARMS) technique. The clinical parameters were obtained through laboratory investigations and clinical examination.

resultsOur results showed obvious statistical significance between cases and control genotypes regarding to SNPs (rs11889341: CC and TT, rs10181656: GG and rs7574865: TT). Additionally, analysis displayed a discrepancy in genotypes frequency of SNPs (rs11889341: CC among family history and Anti-CCP, but TT genotype with RF), (rs7574865: TT within RF and Anti-CCP, GG genotype in relation to family history.

conclusionOur study concluded that STAT4 gene polymorphism (SNPs: rs11889341, rs10181656 and rs7574865) were associated with RA development in Iraqi population. Furthermore, the SNPs (rs11889341 and rs7574865) were related to family history, RF and Anti-CCP, while SNP (rs10181656) didn't display any relation among studied population.

Indexed as

Autoimmune diseaseRheumatoid ArthritisSNPSTAT4 geneTetra-ARMS

Identifiers

PMID41386854
PMCPMC12552942

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