ArticleJournal, genetic engineering & biotechnology2025
In-silico study on biomolecules derived from Cissus quadrangularis towards anti-inflammation.
Article in Journal, genetic engineering & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Exploring the Role ofOrthopedic research and reviews · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCD 163 protein is a macrophage-specific protein and hemoglobin scavenger receptor. Elevated expression of CD 163 protein in macrophages is an important feature indicating that tissues are subjected to inflammation. It can be an effective diagnostic biomarker for inflammatory diseases like gingivitis and periodontitis. Cissus quadrangularis is used as a potent alternative medicine to control inflammation and heal fractured bones. It has high osteogenic potential by increasing osteoblast mineralization. Being a natural product with a wide range of benefits can lead to drug development for its high anti-inflammatory and anti-osteoporotic properties. Studies have shown that Cissus quadrangularis has significant anti-inflammatory potential and can be used as a potential target for therapeutic agents. The objective of the study is to explore the interaction of the phytonutrients derived from Cissus quadrangularis with CD 163 protein to establish the anti-inflammatory activity by in silico approach. MATERIALS AND
methodsThe biomolecules derived from the plant Cissus quadrangularis namely β-Sitosterol, luteolin, piceatannol, quadrangualrin, resveratrol, and tannins were subjected to molecular docking using Autodock of 4.0 PyRx software.
resultsThe study results showed drug-likeness and binding affinity between biologically active Cissus quadrangularis molecules against inflammation associated with CD 163 protein.
conclusionIt can be concluded that the biomolecules derived from Cissus quadrangularis exhibited anti-inflammatory potential and thus it can be further explored by invitro analysis in developing a new drug.
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Registered trials
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