Evidence map›Paper›PMID 41386691›Full record

ArticleHead & neck2026

Chloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma.

Yuki Hosokawa, Shoko Miyoshi, Yuji Hayashi, Yuki Irifune, Eriko Sato, Sohei Mitani, Mohammed Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato

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In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuki HosokawaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.
Shoko MiyoshiDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.
Yuji HayashiDepartment of Otorhinolaryngology, Head and Neck Surgery, Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan.
Yuki IrifuneDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.ORCID 0000-0002-2962-9019
Eriko SatoDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.
Sohei MitaniDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.
Mohammed ChoudhuryDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.ORCID 0000-0002-2658-5487
Hajime YanoDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.ORCID 0000-0002-1615-7526
Junya TanakaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.
Naohito HatoDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Ehime University, Matsuyama, Ehime, Japan.

Funding

Japan society for the promotion of science 23K08988
6 · The paper itself

Abstract

backgroundThe association of chloride intracellular channel 2 (CLIC2) with tumors has remained unclear. However, recently, CLIC2 was found to exhibit antitumor properties in some tumors. In this study, we aimed to evaluate the clinical relevance of CLIC2 expression in head and neck squamous cell carcinoma (HNSCC) to determine whether it exerts antitumor effects similar to those in brain tumors and to explore its potential as a novel therapeutic target in HNSCC.

methodsWe explored the significance of CLIC in HNSCC using cell biological analyses and investigated the gene expression profile of the CLIC2 forced-expressed HNSCC cell line. CLIC2 expression in human HNSCC was examined histopathologically.

resultsForced expression of CLIC2 in HNSCC cells was accompanied by increased cell proliferation, resistance against natural killer cells, and expression of tumor-promoting genes in addition to increased tumorigenicity upon xenografting in a mouse model. CLIC2 expression was observed in several human cases of HNSCC.

conclusionCLIC2 may act potentially as a novel risk factor for HNSCC.

Indexed as

Carcinoma, Squamous CellChloride ChannelsHead and Neck NeoplasmsAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudeMiddle AgedSquamous Cell Carcinoma of Head and NeckChloride Channelschloride intracellular channel 2 (CLIC2)head and neck squamous cell carcinoma (HNSCC)malignant potentialrisk factortherapeutic target

Identifiers

PMID41386691
PMCPMC13055430

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.