Evidence map›Paper›PMID 41386548›Full record

ArticleChemPlusChem2026

Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity.

Periklis Karamanis, Matthew Kiernan, Jimmy Muldoon, Paul Evans, Cormac D Murphy, Marina Rubini

Abstract read
In one paragraph

Article in ChemPlusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Periklis KaramanisUCD School of Chemistry, University College Dublin, Dublin, Ireland.
Matthew KiernanUCD School of Chemistry, University College Dublin, Dublin, Ireland.
Jimmy MuldoonUCD School of Chemistry, University College Dublin, Dublin, Ireland.
Paul EvansUCD School of Chemistry, University College Dublin, Dublin, Ireland.
Cormac D MurphyBiOrbic Bioeconomy SFI Research Centre, University College Dublin, Dublin, Ireland.ORCID 0000-0002-2137-3338
Marina RubiniUCD School of Chemistry, University College Dublin, Dublin, Ireland.ORCID 0000-0002-3102-2558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of antifungal resistance threatens public health and agriculture. Iturin A, a cyclic lipopeptide produced by Bacillus species, is known for its antifungal activity against various pathogens. In this study, three novel trifluoromethylated analogues of iturin A were synthesised as potential

Indexed as

Antifungal AgentsLipopeptidesPeptides, CyclicCandida albicansFusariumMicrobial Sensitivity TestsStructure-Activity RelationshipAntifungal Agentsiturin ALipopeptidesPeptides, Cyclicantifungal agentscyclic lipopeptidesiturin Alate‐stage trifluoromethylationpeptide cyclisationpeptidestrifluoromethylated peptides

Identifiers

PMID41386548
PMCPMC12777510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.