ArticlePlant physiology and biochemistry : PPB2026
Targeting Florida red tide: Curcumin inhibits Karenia brevis thioredoxin reductase.
Article in Plant physiology and biochemistry : PPB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Recurring blooms of the Florida red tide dinoflagellate Karenia brevis, a type of harmful algal bloom (HAB), result in adverse economic, environmental, and public health outcomes. These effects have been largely attributed to the production of a suite of neurotoxins known as the brevetoxins. Recent studies have shown that curcumin, a naturally occurring polyphenol known for its redox-modulating and anticancer effects, can significantly decrease both K. brevis cell counts and brevetoxin concentrations. However, its molecular target remained unknown. In this study, we identified K. brevis thioredoxin reductase (KbTrxR), a key regulator of cellular redox homeostasis, as a direct target of curcumin. Enzyme inhibition assays using 5,5'-Dithiobis (2-nitrobenzoic acid) (DTNB) as a substrate revealed time-dependent inhibition of the KbTrxR by curcumin, with an IC
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