Advanced extraction techniques for sustainable recovery of health-promoting compounds from carob leaves.

Simona Serio, Valentina Santoro, Anna Lisa Piccinelli, Rita Celano, Luca Rastrelli

Abstract read

In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Simona SerioDepartment of Pharmacy, University of Salerno 84084 Fisciano, Salerno, Italy; PhD Program in Drug Discovery and Development, University of Salerno 84084 Fisciano, Salerno, Italy.

Valentina SantoroDepartment of Pharmacy, University of Salerno 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy.

Anna Lisa PiccinelliDepartment of Pharmacy, University of Salerno 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy. Electronic address: apiccinelli@unisa.it.

Rita CelanoDepartment of Pharmacy, University of Salerno 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy.

Luca RastrelliDepartment of Pharmacy, University of Salerno 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carob (Ceratonia siliqua) leaves (CSL) are an underutilized source of health-promoting compounds, including siliquapyranone, 1,2,3,6-tetragalloylglucose and myricitrin. CSL and its main compounds revealed remarkable antioxidant and hypoglycaemic potential. This study presents a systematic optimization of pressurized hot water extraction (PHWE) and probe-based ultrasound-assisted extraction (probe-UAE) as sustainable strategies for the recovery of CSL bioactive compounds. Using response surface methodology combined with UHPLC-UV profiling, the main parameters influencing extraction efficiency and compound stability were identified. Optimal PHWE (98 °C, three 5 min-cycles) and probe-UAE (ethanol 52 %, 100 g L

Indexed as

Chemical FractionationFabaceaeGalactansPlant LeavesAntioxidantsMannansPlant GumsUltrasonic WavesWaterAntioxidantsGalactanslocust bean gumMannansPlant GumsWaterAgricultural co-productsDesign of experimentsFunctional ingredientsGood health and well-being − SDG3Green extractionResponsible consumption and production − SDG12

Identifiers

PMID41386034

DOI10.1016/j.ultsonch.2025.107710

PMCPMC12753491

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.