Evidence map›Paper›PMID 41386033›Full record

ArticleUltrasonics sonochemistry2026

Liposome-integrated ultrasound coupling subcritical water extraction for enhanced the efficiency and stability of Phyllanthus emblica polyphenols.

Shuhui Liang, Xinyi Luo, Zexin Chen, Yushi Gong, Yong Hu, Fenglin Song, Yongguang Bi, Dongmei Li, Juan Guo

Abstract read
In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Development ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuhui LiangSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Xinyi LuoSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zexin ChenSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yushi GongSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yong HuSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Fenglin SongSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yongguang BiSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Dongmei LiSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Juan GuoSchool of Food Science, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: guojuan110@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound coupling subcritical water extraction (USWE) was developed to extract polyphenols from Phyllanthus emblica pomace (PPEPs), and extraction parameters affecting the yield of PPEPs were systematically optimized. USWE was comprehensively evaluated in terms of extraction parameters, yield, antioxidant capacity, major bioactive components, and infrared characteristics of PPEPs, and compared with four other extraction methods. Microstructural changes in the pomace were examined using scanning electron microscopy (SEM) to elucidate the interactions between the extraction process and the plant matrix. Finally, to address the issues of the instability of PPEPs and their low bioavailability, liposomal encapsulation was performed and the physicochemical properties were evaluated. Results demonstrated that the yield of PPEPs from USWE was 1.8-fold and 1.35-fold higher than those from solvent extraction (SE) and subcritical water extraction (SWE), respectively. Furthermore, PPEPs from USWE exhibited the strongest antioxidant activity and higher levels of six major bioactive compounds. SEM analysis revealed a significant increase in porosity and enlarged pores in USWE-treated pomace. Additionally, Phyllanthus emblica polyphenol liposomes (PPEPL) were prepared by thin-film dispersion technique. PPEPL showed a high encapsulation efficiency of 83.07 ± 0.09 % and retained structural integrity after 4 weeks of storage at 4 °C. PPEPL exhibited enhanced antioxidant activity compared to free PPEPs. The IC

Indexed as

Chemical FractionationLiposomesPhyllanthus emblicaPolyphenolsUltrasonic WavesWaterAntioxidantsDrug StabilityAntioxidantsLiposomesPolyphenolsWaterLiposomesPhyllanthus emblica pomacePolyphenolsSubcritical water extractionUltrasound

Identifiers

PMID41386033
PMCPMC12757624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.