ArticleSchizophrenia research2026
Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample.
Article in Schizophrenia research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundMany individuals with schizophrenia have comorbid substance use disorders (SUD) and yet the reasons for this comorbidity are largely unknown. The current study examined if shared genetic effects jointly increase risk for both schizophrenia and SUD and if shared genetic effects on brain structure phenotypes mediate this relationship.
methodsData were collected using a multiplex extended pedigree design ascertained through schizophrenia probands (total sample N = 1306, with N = 789 relatives and N = 517 unrelated controls) to investigate the degree to which genetic effects are shared among schizophrenia, four SUDs, and structural MRI measures of surface area, cortical thickness, and subcortical volumes. Given that all predictions were directional (e.g., that schizophrenia would be positively genetically correlated with substance use), one-tailed t-tests were used with false discovery rate (FDR) correction when appropriate.
resultsAs predicted, schizophrenia was significantly genetically correlated with any SUD excluding nicotine (R
conclusionsThese findings indicate that shared genetic effects may partially explain the observed comorbidity between schizophrenia and SUD and may suggest a unique role of the hippocampus in the pathophysiology of both schizophrenia and SUD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.