Evidence map›Paper›PMID 41385856›Full record

SynthesisThe journal of nutrition, health & aging2026

Effects of nutritional guidance on frailty in older adults: A systematic review.

Tatsuya Koyama, Junko Nohara, Mieko Nakamura

Abstract readSystematic Review
In one paragraph

Synthesis in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tatsuya KoyamaNational Institutes of Biomedical Innovation, Health and Nutrition, National Institute of Health and Nutrition, Japan. Electronic address: t-koyama@nibn.go.jp.
Junko NoharaKio University, Japan.
Mieko NakamuraNational Institutes of Biomedical Innovation, Health and Nutrition, National Institute of Health and Nutrition, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrailty is a prevalent geriatric syndrome associated with risk of disability, hospitalization, and mortality. Despite nutrition and exercise playing central roles in maintaining muscle mass and function, the specific effects of nutritional guidance, distinct from supplementation, remain unclear.

objectiveThis systematic review aimed to evaluate the effectiveness of nutritional guidance interventions on frailty in community-dwelling older adults.

methodsA systematic search in MEDLINE (PubMed) identified relevant randomized controlled trials (RCTs) published up to April 2025. Eligible studies included those with participants aged ≥65 years who received nutritional guidance, defined as dietary counseling or education without supplementation, with frailty status as the primary outcome measure. The risk of bias was assessed using Cochrane RoB 2.0.

resultsFrom 211 initial records, 11 relevant RCTs were included in the analyses. The interventions varied in duration (12 weeks to 8 years), delivery (individual or group sessions), and implementers (dietitians, health professionals, or non-professionals). Short-term interventions produced mixed results, whereas long-term programs, particularly those combined with exercise, showed more consistent improvements in frailty measures. Individually tailored and professionally delivered interventions were generally more effective. However, substantial heterogeneity in intervention design, frailty definitions, and outcome measures limited comparability across studies. Few trials quantitatively assessed dietary intake, restricting mechanistic understanding.

conclusionNutritional guidance can help prevent or improve frailty in older adults, especially when implemented as a long-term, individualized, and professionally delivered program, ideally combined with physical activity. Future research should adopt standardized frailty criteria, reliable dietary assessment methods, and multidisciplinary approaches to strengthen the evidence and inform sustainable strategies for healthy aging.

Indexed as

Frail ElderlyFrailtyAgedAged, 80 and overCounselingExerciseFemaleGeriatric AssessmentHumansIndependent LivingMaleRandomized Controlled Trials as TopicDietary educationFrailtyNutritional guidanceOlder adultsSystematic review

Identifiers

PMID41385856
PMCPMC12757635

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.