[New possibilities of combining immunotherapy and radiotherapy in the definitive treatment of locally advanced cancer diseases].

The spectacular development of radiotherapy technology in the twenty-first century and the everyday availability of this modern technique have founded the possibility of combining radiotherapy with various systemic oncological treatments with increasing safety and effectiveness. The most novel systemic treatment modality, the modern immunotherapy, which is also the achievement of the present century, and the latest milestone in its rapid spread across the therapeutic spectrum in cancer care is the step forward to the treatment of earlier tumor stages with curative intent. The inevitable meeting point of these rapidly developing treatment modalities is the care of locally advanced tumors, achieving the theory and practice of the combination of immunotherapy with definitive radiotherapy. The success of the PACIFIC, ADRIATIC or KEYNOTE-A18 studies proves that further progress is possible in the definitive, curative treatment of locally advanced cancer diseases. In this paper, we describe this combination therapy algorithm, the biological background and the successful or less successful clinical trial results in the most relevant and important tumor types and indications.