Evidence map›Paper›PMID 41385384›Full record

ReviewBriefings in functional genomics2025

Expression and role of deubiquitinating enzymes in thyroid carcinoma.

Meiling Huang, Changjiao Yan, Rui Ling, Ting Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Briefings in functional genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meiling HuangDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, NO 127 Changle West Road, Xi'an Shaanxi 710032,  China.
Changjiao YanDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, NO 127 Changle West Road, Xi'an Shaanxi 710032,  China.
Rui LingDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, NO 127 Changle West Road, Xi'an Shaanxi 710032,  China.
Ting WangDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, NO 127 Changle West Road, Xi'an Shaanxi 710032,  China.ORCID 0000-0003-4121-7532

Funding

Natural Science Foundation of Shaanxi Province 2023-JC-QN-0965
6 · The paper itself

Abstract

Thyroid cancer is one of the most common endocrine diseases worldwide with phenotypic heterogeneity. Deubiquitinating enzymes (DUBs) participated in ubiquitin (Ub) conjugases-induced signal by removing Ub from the substrates. Dysregulation of DUBs are associated with cancer progression, including thyroid carcinoma. In this review, we outline the main classification and structure of DUBs, the expression of DUBs in thyroid cancer, the association of DUBs with survival, and the possible mechanism of DUBs in thyroid cancer progression. Finally, we summarized the development of USP specific inhibitors, the strategies for designing and identifying selective inhibitors.

Indexed as

Deubiquitinating EnzymesThyroid NeoplasmsAnimalsGene Expression Regulation, NeoplasticHumansDeubiquitinating Enzymesdeubiquitinating enzymesDUBs inhibitorspathological associationthyroid carcinoma

Identifiers

PMID41385384
PMCPMC12700091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.