Evidence map›Paper›PMID 41385260›Full record

ArticleMedical care2026

The Association Between Self-Reported Types of Toxic Exposures and Symptom Severity Among Gulf War Era Veterans.

Molly S Phan, Kara Winchell, Elizabeth Hooker, Jennifer Barton, Mark Helfand, Shannon Nugent

Abstract read
In one paragraph

Article in Medical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Molly S PhanVA Portland Health Care System, Portland, OR.
Kara WinchellCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR.
Elizabeth HookerCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR.
Jennifer BartonCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR.
Mark HelfandCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR.
Shannon NugentCenter to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, OR.

Funding

HSRD VA I01 HX002148Wellcome Trust
6 · The paper itself

Abstract

backgroundGulf War illness is a chronic multisymptom illness impacting Veterans of the 1990-1991 Persian Gulf War. Toxic exposures are believed to be associated with the condition, but little is known about how multiple types of exposures can impact the disease. The aim of this study is to determine if a positive association exists between the multiplicity of exposure types and symptom severity score.

methodsA cross-sectional survey design was used in which Persian Gulf Veterans completed a questionnaire with items related to symptom severity and types of self-reported toxic exposures. Linear regression models were used to examine the association between the number of types of toxic exposures and symptom severity scores. We also examined the association between each type of reported exposure and symptom severity score.

resultsVeterans with a greater number of self-reported toxic exposures reported higher scores on symptom severity. While no individual exposure type reached a statistically significant association with symptom score, radiation and biological agent exposures showed the strongest association. DISCUSSION: We found a positive association between the number of toxic exposure types and total symptom severity. Veterans who self-reported having Gulf War Illness also reported more types of toxic exposures compared with Veterans who did not report having Gulf War Illness. Radiation and biological agent exposure showed the strongest positive association with symptom scores, yet very few Veterans reported isolated exposure of these types. Our findings suggest that cumulative exposure to multiple types of toxins could be associated with the development and severity of Gulf War Illness symptoms.

Indexed as

Persian Gulf SyndromeVeteransAdultCross-Sectional StudiesFemaleGulf WarHumansMaleMiddle AgedSelf ReportSeverity of Illness IndexSurveys and QuestionnairesUnited Stateschronic multisymptom illnessGulf War Illnessmilitary toxics

Identifiers

PMID41385260
PMCPMC12704681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.