Evidence map›Paper›PMID 41385259›Full record

SynthesisMedical care2026

Psychiatric Conditions and Symptoms After Toxic Environmental Exposures During Military Service: An Evidence Map.

Anna T Magnante, Shannon M Nugent, Kyle J Bourassa, Nina Leflore-Lloyd, Samantha J Meckes, Adelaide M Gordon, Stephen H Boyle, Dazhe Chen, Amir Alishahi Tabriz, Stephanie Y Wells and 6 more

Abstract readSystematic Review
In one paragraph

Synthesis in Medical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anna T MagnanteW.G. (Bill) Hefner Veterans Affairs Healthcare System, Salisbury, NC.ORCID 0000-0002-6489-8732
Shannon M NugentVA Portland Health Care System, Center to Improve Veteran Involvement in Care, Portland, OR.
Kyle J BourassaVA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC.
Nina Leflore-LloydDurham Veterans Affairs Health Care System, Durham, NC.
Samantha J MeckesVA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC.
Adelaide M GordonDurham Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System, Durham, NC.
Stephen H BoyleCooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, NC.
Dazhe ChenEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC.
Amir Alishahi TabrizDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL.
Stephanie Y WellsVA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC.
Morgan JacobsDurham Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System, Durham, NC.
Julee SnyderEvidence Synthesis Program Center, Durham VA Health Care System, Durham, NC.
Liziqiu YangUniversity of Illinois Urbana-Champaign, Urbana, IL.
Sarah CantrellDuke University Medical Center Library and Archives, Duke University School of Medicine, Durham, NC.
Karen M GoldsteinDurham Veterans Affairs Health Care System, Durham, NC.
Jennifer M GierischDurham Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System, Durham, NC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUS service members are often exposed to a range of service-related hazards. To date, there has been limited synthesis of the existing research conducted on military environmental exposures and subsequent psychiatric conditions and symptoms.

objectiveTo systematically review and characterize the main features of studies examining associations between military exposures and mental health outcomes.

methodsWe used evidence mapping methodology to systematically search MEDLINE, Embase, PsycINFO, and PTSDpubs for studies of toxic exposure during military service and psychiatric outcomes, which included psychiatric diagnoses, psychiatric symptoms, and neurocognitive functioning.

resultsWe identified 49 studies; most were comprised of predominantly White, male veteran samples. Chemical exposures, including chemical munitions from the Gulf War era and Agent Orange from the Vietnam War era, were the most frequently examined military toxic exposures. Symptoms of depression, PTSD, and anxiety were the most commonly examined psychiatric outcomes. Only 9 studies assessed neurocognitive functioning. We found extensive variation in how exposures and outcomes were defined and measured. Most exposure and symptom data were based on self-reports. Overall, available evidence suggests that veterans reporting environmental toxic exposures may report relatively high levels of mental health needs.

conclusionsWe found broad evidence that toxic exposure was associated with poorer mental health outcomes, though the ability to draw stronger conclusions is limited by the quality of the current literature. Future research should focus on longitudinal studies of toxic exposure and mental health that include more broadly representative military populations, including diverse samples and more recent service cohorts.

Indexed as

Environmental ExposureMental DisordersMilitary PersonnelOccupational ExposureVeteransHumansMaleUnited Statesmental healthmilitaryPACT Acttoxic exposuresveterans

Identifiers

PMID41385259
PMCPMC12704669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.