Evidence map›Paper›PMID 41385174›Full record

ArticleNeurology and therapy2026

Association of Post-procedural Glucose with Clinical Outcomes After Endovascular Therapy for Large Vessel Occlusion.

Junling Fu, Chen Gong, Shuyu Jiang, Liping Huang, Xinyu Li, Naoyu Wang, You Wang, Shengli Chen, Tao Xu, Yangmei Chen

Abstract read
In one paragraph

Article in Neurology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Junling Fu *Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chen Gong *Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shuyu Jiang *Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liping Huang *Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xinyu LiDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Naoyu WangDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
You WangDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shengli ChenDepartment of Neurology, Chongqing University Three Gorges Hospital, Chongqing, China.
Tao XuDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. xutao@hospital.cqmu.edu.cn.
Yangmei ChenDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. chenym1997@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-3345-395X

Funding

the Chongqing Technology Innovation and Application Development Project CSTB2022TIAD-KPX0160the Joint Project of Chongqing Health Commission and Science and Technology Bureau Tao Xuthe Science and Technology Research Program of Chongqing Education Commission of China KJQN202300402
6 · The paper itself

Abstract

introductionGlucose at admission predicted poor outcome for patients with acute large vessel occlusion (LVO) undergoing endovascular therapy (EVT). Prior studies ignored continuous glucose monitoring after EVT. Therefore, we aim to evaluate the association between post-procedural glucose levels and outcomes in real-world settings.

methodsThis study was based on a multicenter cohort. Patients with LVO who underwent EVT within 24 h of symptom onset were enrolled. We analyzed post-procedural blood glucose based on preprandial blood glucose levels within 48 h after EVT recognizing disrupted normal dietary patterns and circadian rhythms due to severe symptoms of LVO. Primary clinical outcome was functional independence (90-day modified Rankin scale score 0-2). We evaluated the association between post-procedural glucose and functional independence using logistic regression and assessed whether stroke severity modified this association.

resultsA total of 693 patients were included. Multivariate logistic regression analysis showed that decreased average post-procedural glucose per unit was significantly related to functional independence (adjusted odds ratio [aOR]: 0.75, 95% confidence interval [CI] 0.68-0.83, P < 0.001). Hyperglycemia was defined as any preprandial blood glucose within 48 h after EVT ≥ 7.6 mmol/L based on the restricted cubic spline regression model. The hyperglycemia group was also significantly associated with functional independence (aOR: 0.54, 95% CI 0.36-0.82, P = 0.003), symptomatic intracranial hemorrhage (aOR: 2.16, 95% CI 1.08-4.34, P < 0.001), and 90-day mortality (aOR: 1.71, 95% CI 1.04-2.79, P = 0.033). Subgroup analysis specifically in individuals with severe stroke (defined as National Institutes of Health Stroke Scale [NIHSS] ≥ 15) showed that hyperglycemia was a risk factor for low functional independence.

conclusionIncreased post-procedural glucose is associated with poor functional outcome after endovascular treatment and an increased risk of symptomatic intracranial hemorrhage after endovascular treatment, especially for those with more severe strokes.

Indexed as

Blood glucoseEndovascular therapyFunctional independenceLarge vessel occlusion

Identifiers

PMID41385174
PMCPMC12804510

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