ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2025
Exploring HSI imagery for overlapped chromosomes segmentation.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The segmentation of overlapping chromosomes in metaphase images is a longstanding challenge in cytogenetics, where limited spectral contrast in conventional RGB imaging. In this study, we explore hyperspectral imaging (HSI) as a promising alternative modality to enhance segmentation accuracy by exploiting information from a narrow band of the spectrum. To evaluate the benefit of spectral data, we acquired and annotated a dedicated dataset of overlapping chromosomes, using a hyperspectral microscopy system. Multiple segmentation baseline models were trained and benchmarked on both RGB and HSI data. Experimental results show that HSI-based models consistently outperform RGB-based counterparts, achieving up to 92% Dice score. These findings underline the potential of HSI for improving cytogenetic image analysis and provide a new benchmark dataset for future research in spectral segmentation.
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