ArticleWiener klinische Wochenschrift2026
Performance of the automated DNA extraction with MagNA Pure 24 for further genetic testing for hemoglobinopathies with Globin StripAssays.
Article in Wiener klinische Wochenschrift, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiagnosing hemoglobinopathies through reverse hybridization with Globin StripAssays (ViennaLab, Vienna, Austria) is widely performed. There are only two authorized hands-on DNA extraction methods for these assays: the spin Micro DNA Extraction Kit (ViennaLab, Vienna, Austria) for the α‑Globin StripAssay and GEN
methodsWe analyzed blood samples of 41 patients with clinical suspicion of hemoglobinopathies. As the gold standard we stipulated the ViennaLab DNA extraction methods and compared them to the MagNA Pure 24 Total Isolation Kit performed on MagNA Pure. The results of the different test strips were qualitatively classified with respect to good and weak read outs, background signals as well as true/false positives or negatives.
resultsA total of 6226 StripAssay lines were analyzed. After extraction with the gold standard 98.3% had a good read out, 0.9% a weak read out and in 0.9% a background signal was identified. After extraction with MagNA Pure 99.4% had a good read out, 0.2% a weak read out and a background signal was found in only 0.5% of the lines (P < 0.001) and there were no false positives or negatives (sensitivity and specificity 100.0%).
conclusionThe automated DNA extraction with MagNa Pure showed noninferior results when compared with the Spin Micro and GEN
Indexed as
Identifiers
41385086What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.