ArticleInfectious diseases and therapy2026
Long-Term Antibody Persistence After Hepatitis A Vaccination in Healthy Toddlers: Insights from Modeling.
Article in Infectious diseases and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Long-Term Persistence of Hepatitis A Virus Immunity in Healthcare Workers Upto 25 Years After Vaccination.Journal of viral hepatitis · 2026Article
- Pre-Travel Consultation for the Prevention of Infectious Diseases among International Travelers from GCC Countries: Travel Medicine Recommendations for Clinicians.Saudi journal of medicine & medical sciencesReview
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionArgentina was the first South American country to adopt a single-dose hepatitis A vaccine for 1-year-old children, replacing the standard two-dose regimen in the immunization program in 2005. Here, we assessed the long-term persistence of anti-hepatitis A virus (HAV) antibodies following vaccination.
methodsA cohort of healthy toddlers from Mendoza, Argentina, who received one (N = 436) or two (N = 108) doses of the inactivated HAV vaccine (Avaxim
resultsAt year 15, anti-HAV antibody geometric mean concentrations (GMCs) were 73.7 (95% CI 65.0-83.6) mIU/ml and 291.1 (95% CI 226.1-375.0) mIU/ml among those who received one and two vaccine doses, respectively, and all remained seroprotected. Of the four model specifications tested, the log-logistic model with natural boosting provided the best fit to the observed antibody GMCs and seroprotection rates. At 40 years post-vaccination, GMCs were predicted to be 51.8 (95% CI 36.8-75.1) mIU/ml and 134.7 (95% CI 84.5-221.1) mIU/ml after one and two vaccine doses, respectively, with seroprotection rates of 94% (95% CI 89-98) and 93% (95% CI 88-97).
conclusionsThe HAV vaccine, Avaxim
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