Evidence map›Paper›PMID 41385054›Full record

ArticleThe international journal of cardiovascular imaging2026

Cardiac and renal sympathetic nerve activation in early-stage HFpEF: insights from

Meijing Shi, Zhiqiang Yang, Pei Yin, Huayi Zhao, Lizhuo Li, Yuzhi Zhen, Qingzhen Zhao, Chao Liu

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In one paragraph

Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meijing ShiSchool of Graduate, Hebei Medical University, Shijiazhuang, 050031, Hebei Province, China.ORCID http://orcid.org/0009-0008-6148-4033
Zhiqiang YangSchool of Graduate, Hebei Medical University, Shijiazhuang, 050031, Hebei Province, China.
Pei YinDepartment of Radiology and Nuclear Medicine, First Affiliated Hospital of Hebei Medical University, Hebei Province, 050031, China.
Huayi ZhaoDepartment of Radiology and Nuclear Medicine, First Affiliated Hospital of Hebei Medical University, Hebei Province, 050031, China.
Lizhuo LiDepartment of Cardiology, Heart Center, First Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei Province, China.
Yuzhi ZhenDepartment of Cardiology, Heart Center, First Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei Province, China.
Qingzhen ZhaoDepartment of Cardiology, Heart Center, First Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei Province, China.
Chao LiuDepartment of Cardiology, Heart Center, First Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei Province, China. liuchao@hebmu.edu.cn.ORCID http://orcid.org/0000-0002-5323-6733

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While sympathetic overactivity is a well-established driver of disease progression in heart failure with reduced ejection fraction, its role in early-stage heart failure with preserved ejection fraction (HFpEF) remains unclear. In particular, renal sympathetic activity-an important contributor to neurohormonal dysregulation-has not been systematically evaluated in HFpEF. Early-stage HFpEF refers to patients who present with mild symptoms, only modest elevations in B-type natriuretic peptide (BNP), and invasively confirmed elevated left ventricular end-diastolic pressure (LVEDP) but without overt structural remodeling or severe congestion. We conducted a single-center retrospective randomized controlled study including 121 patients with early-stage HFpEF and 44 matched controls. All participants underwent

Indexed as

3-IodobenzylguanidineHeartHeart FailureKidneyRadionuclide ImagingRadiopharmaceuticalsStroke VolumeSympathetic Nervous SystemVentricular Function, LeftAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective Studies3-IodobenzylguanidineRadiopharmaceuticals131I-MIBGCardiac innervationHeart failure with preserved ejection fractionRenal sympathetic activityScintigraphySympathetic nervous system

Identifiers

PMID41385054

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.