SynthesisJournal of neuro-oncology2025
Effects of proton therapy on cognition in adults with brain tumors: a systematic review.
Synthesis in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProton therapy (pt) is increasingly employed in treating of intracranial neoplasms due to its ability to spare surrounding healthy tissue. However, its effects on cognitive function in adult patients remain unclear, despite rising clinical adoption. This review systematically evaluates evidence on neurocognitive outcomes in adults treated with pt for primary intracranial tumors, and assess its impact across multiple cognitive domains.
methodsThis review followed PRISMA guidelines and was registered on PROSPERO (ID: CRD42024591714). Eligible studies included adults ( > 18 years) with primary brain tumors treated with PT and assessed using standardized neuropsychological tests. Pediatric populations, metastases, self-report-only assessments, and other radiotherapy techniques were excluded. Literature was searched across PubMed, Embase, and Scopus. Methodological quality was appraised using the Mixed Methods Appraisal Tool.
resultsEight studies comprising 310 patients (247 receiving PT) were included. Tumor types varied and included gliomas, meningiomas, craniopharyngiomas, and others. Overall, PT was associated with stable or improved outcomes in global cognition, memory, language, executive function, attention, working memory, and visuospatial abilities. No study reported progressive cognitive decline. Improvements were often observed over long-term follow-up, particularly in patients without treatment-induced toxicity. Subgroup analyses revealed better recovery in left-sided lesions and worse outcomes in patients with radiation-induced brain lesions or toxicities.
conclusionPT appears to be a cognitively sparing modality for treating intracranial neoplasms in adults. While most cognitive domains are preserved or improve over time, patients experiencing treatment-related toxicities may be at higher risk of impairment. Future large-scale, multicenter trials with longer follow-ups and domain-specific assessments are warranted to confirm these findings and optimize treatment protocols.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.