Cytometric Analysis of CD3 + CD4 + T Populations and Activation and Regulation Status of Naïve and Memory CD4 + CD45RA T Cells in Immunocompetent Patients with Neurocryptococcosis.

Isabel Feitosa Maciel, Juliana Ruiz, Renata Buccheri de Oliveira, Paula Ordonhez Rigato, Victor Angelo Folgosi, Roseli Santos de Freitas-Xavier, Dewton de Moraes Vasconcelos

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Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Isabel Feitosa MacielDermatology and Immunodeficiency Research Laboratory (LIM56), Department of Dermatology, Hospital das Clínicas, School of Medicine, University of São Paulo., São Paulo-SP, Brazil. biomed.isabelmaciel@alumni.usp.br.ORCID http://orcid.org/0000-0002-3515-7214

Juliana RuizDermatology and Immunodeficiency Research Laboratory (LIM56), Department of Dermatology, Hospital das Clínicas, School of Medicine, University of São Paulo., São Paulo-SP, Brazil.ORCID http://orcid.org/0000-0003-2127-8493

Renata Buccheri de OliveiraVitalant Research Institute, University of California, San Francisco, USA.ORCID http://orcid.org/0000-0002-3217-5898

Paula Ordonhez RigatoImmunobiology and Biomarkers Laboratory, Immunology Center, Adolfo Lutz Institute, São Paulo-SP, Brazil.ORCID http://orcid.org/0000-0002-4416-3544

Victor Angelo FolgosiDermatology and Immunodeficiency Research Laboratory (LIM56), Department of Dermatology, Hospital das Clínicas, School of Medicine, University of São Paulo., São Paulo-SP, Brazil.ORCID http://orcid.org/0000-0002-0114-7587

Roseli Santos de Freitas-XavierMicrobiology Laboratory, Central Laboratory Division and Laboratory Pathology Laboratory (LIM 03Department of PathologyFaculdade de Medicina, Hospital das Clinicas, Universidade de São Paulo., São Paulo-SP, Brazil.ORCID http://orcid.org/0000-0001-5811-5255

Dewton de Moraes VasconcelosDermatology and Immunodeficiency Research Laboratory (LIM56), Department of Dermatology, Hospital das Clínicas, School of Medicine, University of São Paulo., São Paulo-SP, Brazil.ORCID http://orcid.org/0000-0002-3930-3354

Funding

CAPES 33002010060P2

6 · The paper itself

Abstract

Neurocryptococcosis is a serious disease that mainly affects individuals with compromised immune systems. However, "immunocompetent" individuals are also affected by this condition even without any known underlying disease or compromised immune system. In this study, we evaluated the CD4 + T lymphocyte population and subpopulations in the peripheral blood of eight hospitalized patients with neurocryptococcosis and eight healthy control individuals. Thus, our objective was to contribute to this understanding by characterizing the T lymphocyte population (CD3 + CD4 +) and subpopulations, with analyses of the activation and regulation status of responsive T cells in naïve (N), central memory (TMC), effector memory (TME), and terminally differentiated effector (TEMRA) in apparently immunocompetent patients and healthy control individuals. Our results showed a significant increase in CD4 + γδ T subpopulations, CD4 + CD25 + CD127

Indexed as

CD3 ComplexCD4-Positive T-LymphocytesImmunologic MemoryLymphocyte ActivationMemory T CellsMeningitis, CryptococcalT-Lymphocyte SubsetsAdultAgedFemaleFlow CytometryHumansImmunophenotypingLeukocyte Common AntigensMaleMiddle AgedCD3 ComplexLeukocyte Common AntigensCryptococcal meningitisCryptococcus gattiiCryptococcus neoformansEpidemiology of cryptococcosisImmunocompetent patientsVirulence factors

Identifiers

PMID41384991

DOI10.1007/s11046-025-01030-9

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.