Evidence map›Paper›PMID 41384973›Full record

ArticlePsychopharmacology2025

Nicotine delivery from and user reactions to nicotine pouches compared to cigarettes.

Dunja Przulj, Katie Myers Smith, Hayden McRobbie, Francesca Pesola, Irina Ananina, Daniella Ladmore, Peter Hajek

Abstract read
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In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dunja PrzuljWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK. d.przulj@qmul.ac.uk.
Katie Myers SmithWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.
Hayden McRobbieWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.
Francesca PesolaWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.
Irina AnaninaWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.
Daniella LadmoreWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.
Peter HajekWolfson Institute of Population Health, Queen Mary University of London, 2 Stayner's Road, London, E1 4AH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleLimited data exist on the potential of nicotine pouches to help smokers quit.

objectivesTo examine nicotine delivery from and user reactions to a popular nicotine pouch.

methodsTwenty smokers provided data after overnight abstinence, first after smoking a cigarette and then, a week or more later, after using 9 mg nicotine ZYN pouch. Blood samples were collected before and 2, 4, 6, 8, 10 and 30 min (and also 60 min in the pouch condition) after starting product use. Participants also rated their urges to smoke at 5, 10, 15 and 30 minutes, and provided ratings of pouch characteristics at the end of the session.

resultsPouches delivered nicotine more slowly than cigarettes (Tmax 30 min vs. 6 min, z =-3.93, p < 0.001), though nicotine levels from pouches reached 13 ng/ml within 10 min. Cmax was higher than from cigarettes (27.9 vs. 19.5 ng/ml, t (19) =-2.17, p = 0.043). Both products had the same effect on reducing urges to smoke over 30 min although cigarettes were more effective at 5 min. With pouches, urges to smoke remained low at 60 min. Pouches were rated as delivering more nicotine and being less pleasant than cigarettes; but as effective and as fast in reducing urges to smoke. Three participants who were light smokers experienced nausea and one vomited.

conclusionsThe initial appeal of pouches to smokers is likely to be more limited than the appeal of products that resemble smoking more closely, and ZYN pouches with 9 mg of nicotine may be too strong for light smokers. However, in terms of nicotine delivery and effects on urges to smoke, pouches have good potential to provide effective replacement for smoking.

Indexed as

CigarettesNicotineNicotine pouchSmoking cessationTobacco dependence

Identifiers

PMID41384973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.