Evidence map›Paper›PMID 41384896›Full record

ArticleJACC. Case reports2026

Dual Cardiotoxicity of Capecitabine: Coronary Vasospasm and QT Prolongation in a Patient With Gastric Adenocarcinoma.

Adriana Dominguez-Linares, Ana Karen Nieto-Dolores, Leonor E Ayala-Bustamante, Hugo Armando Valencia Hernandez, Enrique Ruiz-Mori, Alfonso Gonzalez-Trejo, Enrique C Guerra, Gilberto H Acosta-Gutierrez, Camila Ponce-Acosta, Nilda Espinola-Zavaleta

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adriana Dominguez-LinaresCardio Oncology Department, National Institute of Neoplastic Diseases, Surquillo, Lima, Peru.
Ana Karen Nieto-DoloresFaculty of Medicine, Popular Autonomous University of Puebla, Puebla City, Mexico.
Leonor E Ayala-BustamanteCardio Oncology Department, National Institute of Neoplastic Diseases, Surquillo, Lima, Peru.
Hugo Armando Valencia HernandezSchool of Medicine, Villa Rica University, Boca del Río, Mexico.
Enrique Ruiz-MoriCardio Oncology Department, National Institute of Neoplastic Diseases, Surquillo, Lima, Peru; Cardiology Department, National Institute of Neoplastic Diseases, Lima, Peru; San Martin Porres University, Santa Anita, Peru.
Alfonso Gonzalez-TrejoFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Enrique C GuerraMD-PhD (PECEM) Program, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Gilberto H Acosta-GutierrezFaculty of Medicine and Biomedical Sciences, Autonomous University of Chihuahua, Chihuahua, Mexico.
Camila Ponce-AcostaMexican Faculty of Medicine, La Salle University, Mexico City, Mexico.
Nilda Espinola-ZavaletaDepartment of Nuclear Cardiology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico. Electronic address: niesza2001@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFluoropyrimidines such as 5-fluorouracil and its oral prodrug capecitabine are widely used in treating gastrointestinal malignancies but are associated with potentially severe cardiotoxicity. CASE SUMMARY: We present the case of a 67-year-old woman with resected gastric adenocarcinoma (pT4apN1) treated with adjuvant XELOX (capecitabine plus oxaliplatin). On the fifth day of the first cycle, she developed severe oppressive chest pain and acute dyspnea. Electrocardiogram showed repolarization changes and QT prolongation, while echocardiography demonstrated preserved ejection fraction. Coronary computed tomography ruled out obstructive disease, and symptoms resolved after drug withdrawal, supporting diagnosis of capecitabine-induced coronary vasospasm. Chemotherapy was safely reintroduced under cardiologic prophylaxis.

conclusionsThis case illustrates the dual cardiotoxicity of capecitabine, with both vasospastic angina and QT prolongation.

Indexed as

capecitabinecardio oncologycardiotoxicityCELOX regimencoronary vasospasmgastric adenocarcinomaQT prolongation

Identifiers

PMID41384896
PMCPMC12881262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.