ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
High Phosphate Load Induces De Novo Formation of Tertiary Lymphoid Structures in the Kidney.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- High Phosphate Load Induces De Novo Formation of Tertiary Lymphoid Structures in the Kidney.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tertiary lymphoid structures (TLS) are associated with inflammatory kidney diseases, but their pathogenesis is unclear. A chronic high phosphate diet (HPD) in mice increases serum levels of phosphate and fibroblast growth factor 23 (FGF23) which is associated with progressive tubule damage and fibrosis. We hypothesized that chronic HPD induces TLS in the kidneys and thereby promotes progressive kidney injury. After only 2 months, mice on HPD showed increased tubule damage accompanied by the formation of perivascular immune cell clusters of B and T cells in the corticomedullary zone and in the cortex. In addition, lymphatic vessels were observed, accompanied by increased expression of venous markers and cell adhesion molecules. Further analyses showed a time-dependent induction of the immunofibroblast-derived chemokines and lymphotoxins, which are important for the differentiation of immunofibroblasts into follicular dendritic cells (FDC) and fibroblastic reticular cells (FRC). Already after 4 months of HPD, proliferating B-cell clusters with FDCs, T-cell clusters with FRCs, podoplanin
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