Evidence map›Paper›PMID 41384749›Full record

ArticlemBio2026

Flow-induced bending of flagella restricts

Jessica-Jae S Palalay, Joseph E Sanfilippo

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Detoxification of host-relevant HbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jessica-Jae S PalalayDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0009-0009-9400-7134
Joseph E SanfilippoDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-8775-5179

Funding

Bacterial stress responses and surface adhesion in shear flowR35GM155443 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Joseph Sanfilippo · 2024 to 2026
$1.1M
Mechanobehavior of Pseudomonas aeruginosa in shear flowK22AI151263 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SANFILIPPO, JOSEPH · 2021 to 2022
$267k
NIAID NIH HHS K22 AI151263NIGMS NIH HHS R35 GM155443
6 · The paper itself

Abstract

Shear force associated with flow can bend, twist, or stretch cellular appendages. Bacterial appendages such as flagella can rotate and generate forces. However, it is unclear how environmental and cell-generated forces interact as bacteria associate with surfaces. Here, we use microfluidics, flagellar labeling, and genetics to discover that flow bends flagella to restrict surface departure of the human pathogen IMPORTANCE: Bacteria use cell appendages such as flagella to interact with their environment. While bacteria are typically studied in conditions that lack flow, host environments are often flowing. In this study, we use microfluidic devices to test how host-relevant flow impacts flagella of the human pathogen

Indexed as

FlagellaPseudomonas aeruginosaMicrofluidicsRotationflagellaflowmicrofluidicsPseudomonas aeruginosashear force

Identifiers

PMID41384749
PMCPMC12802323

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.