ArticleJournal of pediatric gastroenterology and nutrition2026
Therapy de-escalation in paediatric patients with inflammatory bowel disease in remission: Data analysis from the CEDATA registry.
Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Risks of Undertreatment and Overtreatment in Pediatric Inflammatory Bowel Disease: Navigating the Balance.Paediatric drugs · 2026Review
- Therapy de-escalation in paediatric patients with inflammatory bowel disease in remission: Data analysis from the CEDATA registry.Journal of pediatric gastroenterology and nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesThere are no standardized criteria about stepping down from combination therapy (immunomodulator and tumor necrosis factor (TNF)-alpha-inhibitors) in children with inflammatory bowel disease (IBD) to reduce risk for side effects. Our aim was to describe how de-escalation has been performed in a large paediatric cohort and to find prognostic factors for therapy de-escalation without the need for therapy adjustments post-de-escalation.
methodsReal-world data from CEDATA-GPGE, a German-Austrian registry for paediatric IBD patients, from 2004 to 2023, were analyzed. Patients not requiring therapy adjustments post-de-escalation and patients requiring therapy adjustments after de-escalation were compared, and prognostic factors were identified.
resultsTwo hundred and thirty out of 6248 registered patients received combination therapy for at least 6 months. In 64 patients therapy adjustment was not required after de-escalation. Crohn's disease (CD) patients, younger patients, and patients with positive modified predictors of poor outcome were significantly more often on combination therapy. Regarding de-escalation, CD patients were more often successfully de-escalated than ulcerative colitis (UC) and IBD-unclassified patients. UC patients with a less severe disease manifestation (Paris classification E1 or E2) were de-escalated more successfully than those with more extensive disease (E3 or E4). De-escalation to monotherapy with a biologic led to a more successful de-escalation than de-escalation to immunomodulator monotherapy or stopping both biologic and immunomodulator.
conclusionsDe-escalation is more likely successful in patients with CD, and de-escalating combination therapy to monotherapy with a TNF-alpha-inhibitor is more advantageous.
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