ArticleFrontiers in physiology2025
Computationally-directed mechanical ventilation in a porcine model of ARDS.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite the implementation of protective mechanical ventilation, ventilator-induced lung injury remains a significant driver of ARDS-associated morbidity and mortality. Mechanical ventilation must be personalized and adaptive for the patient and evolving disease course to achieve sustained improvements in patient outcomes. In this study, we modified a military-grade transport ventilator to deliver the airway pressure release ventilation (APRV) modality. We developed a computationally-directed (CD) method of adjusting the expiratory duration (T Methods: Female Yorkshire-cross pigs (n = 27) were ventilated using a ZOLL EMV+® 731 Series ventilator during general anesthesia and subjected to a heterogeneous Tween lung injury followed by injurious mechanical ventilation. Animals were subsequently ventilated for 6 hours under general anesthesia after randomization to one of three groups: V Results: All groups developed moderate-to-severe ARDS and had similar recovery in lung injury, with all demonstrating final PaO Conclusion: We successfully implemented a computationally directed APRV modality on a transport ventilator, adjusting T
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