Evidence map›Paper›PMID 41384244›Full record

ReviewFrontiers in physiology2025

The order of things: phosphate release or the power stroke, which does actomyosin do first?

Edward P Debold, Christopher P Marang, Brent D Scott

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Edward P DeboldDepartment of Kinesiology, University of Massachusetts, Amherst, MA, United States.
Christopher P MarangDepartment of Chemical Engineering, Stanford University, Palo Alto, CA, United States.
Brent D ScottDepartment of Health Sciences, College of William and Mary, Williamsburg, VA, United States.

Funding

Load dependent properties of a single molecular motor determines ensemble behaviorR35GM156218 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Edward P. Debold · 2025 to 2026
$798k
NIGMS NIH HHS R35 GM156218
6 · The paper itself

Abstract

Myosins are a highly conserved super family of motor proteins that are responsible for driving a host of intracellular processes in eukaryotes, from muscle contraction to vesicular transport. Myosins can perform these tasks because they transduce chemical energy, from the hydrolysis of ATP into mechanical work, in the form of a power stroke. The key event in the transduction process is the putative coupling of P

Indexed as

actinforce generationmyosinphosphatepower stroke

Identifiers

PMID41384244
PMCPMC12689349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.