ArticleCureus2025
Craniofacial Radiographic Features in Amelogenesis Imperfecta: A Case-Control Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives This study aimed to assess the craniofacial characteristics of individuals with amelogenesis imperfecta (AI) through cephalometric data analysis. Methods The sample comprised 19 patients (11 female, 8 male), with a mean age of 14.00 ± 4.61 years, diagnosed with AI, and 40 age- and sex-matched healthy controls with normal occlusion and balanced profiles. Twenty-three cephalometric variables were used for quantitative assessment. Differences were compared between groups using Student's t-test (p < 0.05). Results Open-bite malocclusion was observed in 57.9% of individuals with AI. The vertical skeletal relationship showed increased anterior facial height, mandibular plane angle, and gonial angles compared to controls (p < 0.01). The skeletal sagittal relationship exhibited a Class II pattern with a retruded mandibular position (p < 0.01), while the maxillary and mandibular lengths showed no significant differences. Additionally, analysis across the four main AI subtypes revealed no significant differences in craniofacial morphology (p > 0.05). Conclusions Excessive vertical growth appears to be the primary cause of the high prevalence of anterior open bite (AOB) in AI patients. These findings suggest that AI-related enamel defects may indirectly influence skeletal growth patterns, warranting early orthodontic monitoring and specialized care.
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