Immunoinflammatory Mechanisms Connecting Periodontitis and Solid Tumors: A Systematic Review of Original Evidence.

Mounting evidence indicates that periodontitis may play a contributory role in the pathogenesis of systemic diseases, including cancer, primarily through mechanisms involving chronic inflammation and immune dysregulation. Nonetheless, the specific immunoinflammatory pathways that underpin the relationship between periodontitis and solid tumors remain only partially elucidated. To conduct a systematic review of original clinical studies that examine the immunoinflammatory mechanisms potentially linking periodontitis with the initiation or progression of solid malignancies. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 framework, we conducted a comprehensive literature search across four major databases (PubMed, Scopus, Web of Science, and Embase) through March 2025. Eligible studies were limited to original human research that investigated the association between periodontitis and solid tumors with an emphasis on immunological or inflammatory biomarkers. Following a rigorous screening process, 19 studies met the inclusion criteria and were analyzed. A consistent body of evidence across the included studies suggests a significant association between periodontitis and heightened risk or severity of various solid tumors, notably colorectal, pancreatic, lung, prostate, and breast cancers. Common immunoinflammatory signatures observed among affected individuals included elevated systemic levels of cytokines, such as IL-6 and TNF-α, altered immune cell profiles characterized by increased regulatory T-cells, and evidence of microbial translocation involving pathogens, including