ArticleFrontiers in endocrinology2025
The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Optimizing the Endometrial Factor in Recurrent Implantation Failure: From Established Diagnostics to Mechanism-Informed Management.Journal of clinical medicine · 2026Review
- Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the impact of endometrial thickness (EMT) variations on clinical outcomes in two distinct ovarian stimulation protocols: the early-follicular long-acting GnRH agonist protocol and the midluteal short-acting GnRH agonist long protocol. Methods: This retrospective cohort study analyzed 21,290 first-time IVF/ICSI fresh embryo transfer cycles conducted at the Reproductive Center of the First Affiliated Hospital of Zhengzhou University between January 2013 and December 2020. Restricted cubic spline (RCS) analysis was employed to assess the relationship between EMT and clinical pregnancy outcomes. Results: In the early-follicular long-acting GnRH agonist protocol group, both clinical pregnancy and live birth rates increased with EMT up to 10.6 mm, beyond which the rates plateaued. Conversely, in the midluteal short-acting GnRH agonist long protocol group, a continuous positive correlation was observed between EMT and both clinical pregnancy and live birth rates. Overall, the early-follicular long-acting protocol demonstrated superior pregnancy outcomes compared to the midluteal short-acting protocol when EMT was less than 15 mm. However, when EMT was ≥15 mm, both protocols yielded comparable clinical pregnancy and live birth rates. Conclusion: The study indicates that in the early-follicular long-acting GnRH agonist protocol, increasing EMT up to 10.6 mm is associated with improved clinical pregnancy and live birth rates, with no further benefits observed beyond this threshold. In contrast, the midluteal short-acting GnRH agonist long protocol exhibits a continuous positive relationship between EMT and pregnancy outcomes. Overall, the early-follicular long-acting protocol offers better clinical outcomes for patients with EMT less than 15 mm, while both protocols perform similarly when EMT is ≥15 mm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.