ArticleFrontiers in endocrinology2025
Incidence of miscarriages in women with children with 47,XXY, 48,XXXY, or 49,XXXXY.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Case Report: An exploration of the neurodevelopmental phenotype of five patients with 48,XXYY during early childhood years.Frontiers in endocrinology · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The management and the causes of miscarriages present challenges for the obstetrical community as well as for families. In families who have a child with an X and Y chromosomal disorder, the duress of pregnancy loss may be significantly exacerbated. A greater understanding of these mechanisms would inform medical providers and families of children with 47,XXY, or Klinefelter syndrome (KS), and variant disorders (48,XXXY and 49,XXXXY). This study investigates miscarriage incidences across a cohort of mothers of male offspring born with these disorders. Methods: Pregnancy history of mothers of male offspring with 47,XXY (KS) or variant disorders was collected. Statistical analyses were performed to determine if these mothers experienced higher incidences of miscarriage than the general population. Results: Mothers reporting miscarriage in the 47,XXY ( Conclusion: Mothers of children with 47,XXY (KS) and variant disorders are at increased risk of miscarriage compared to the general population based on the findings of this study.
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