ArticleOncology letters2026
Differential gene expression analysis reveals signaling pathways of proliferation, angiogenesis and metastasis is associated with interferon suppression in advanced hypopharyngeal cancer cells.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chiropteran (Animals : an open access journal from MDPI · 2026Article
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6 authors.
Funding
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Abstract
Hypopharyngeal cancer (HPC) is a highly aggressive cancer with a poor prognosis due to frequent metastasis and resistance to therapy. However, genes associated with the malignancy of advanced HPC remain to be elucidated. To investigate molecular changes associated with HPC progression, RNA sequencing was performed to compare transcriptomic profiles between parental FaDu HPC cells and advanced FaDu cells (FaDuex) derived from late-stage xenograft tumors. The present analysis revealed 86 markedly upregulated genes and 166 markedly downregulated genes in FaDuex cells compared with FaDu cells. Gene set enrichment analysis revealed enrichment of pathways associated with epithelial-mesenchymal transition and cell proliferation among upregulated genes, whereas downregulated genes were associated with metastasis inhibition, angiogenesis suppression and immune response regulation. Notably, several interferon (IFN)-stimulated genes were suppressed in advanced cells, indicating impaired IFN signaling and reduced antitumor immune responses. The most notable changes in the expression levels of genes associated with these tumor characteristics were then validated using quantitative PCR. These findings suggest that genes associated with tumor malignancy and immunosuppressive pathways potentially contribute to HPC progression and highlight potential molecular targets for diagnostic and therapeutic intervention in the future.
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