ArticleNeuroprotection (Chichester, England)2025
Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta-analysis.
Article in Neuroprotection (Chichester, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Comment on "Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta-analysis".Neuroprotection (Chichester, England) · 2026Article
- Novel approaches for neuroprotection: Focus on neurodegenerative and ischemic central nervous system diseases.Neuroprotection (Chichester, England) · 2026Article
- Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta-analysis.Neuroprotection (Chichester, England) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Some research suggests that vitamin E may help prevent intraventricular hemorrhage (IVH) in preterm neonates. However, consolidated evidence regarding its effects on brain vascular health in this population is lacking. This study systematically reviews primary research on this topic. This study examines the effectiveness of vitamin E supplementation in preventing IVH in preterm neonates than a placebo, thus addressing gaps in the literature. Methods: The Cochrane, Dimensions, Embase, and PubMed databases were searched for relevant studies based on specific inclusion criteria. Subsequently, the relevant data were extracted, and statistical analysis was conducted using R studio (version 4.3.1) by applying appropriate models to account for heterogeneity and generate a combined estimate. The results were interpreted considering potential biases and limitations. Results: Five studies involving 554 patients were included. Among them, 274 (49.45%) received vitamin E. The results (relative ratio 0.57; 95% confidence interval 0.35-0.92; Conclusion: These findings highlight the potential therapeutic benefits of vitamin E supplementation in preterm neonates, which show a significant reduction in IVH incidence than placebo. Further research and clinical trials are required to fully explore its protective effects in this population.
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