ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Amyloid-negative neuropsychological norms: Added value in the era of biomarkers and disease-modifying therapies.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Clinical Impact and Prognostic Value of Alzheimer Disease Biomarkers in the Very Old.Neurology · 2026Article
- Amyloid-negative neuropsychological norms: Added value in the era of biomarkers and disease-modifying therapies.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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30 authors.
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Abstract
introductionWe previously applied generalized additive models for location, scale, and shape to derive amyloid β-negative next-generation norms (NGN) for a comprehensive neuropsychological battery. Here, we evaluated the accuracy of NGN in detecting cognitive impairment compared to traditional norms (TN).
methodsThis multicenter study included
resultsNineteen percent of TN-classified CN participants were diagnosed with MCI by NGN, whereas 3% of TN-classified MCI were identified as CN by NGN. NGN demonstrated stronger associations with neuropsychological performance, AD biomarkers, and progression than TN. DISCUSSION: NGN enhance the detection of objective cognitive impairment, with direct implications for clinical practice and research. Highlights: Next-generation norms (NGN) reclassify one of every five cases from cognitively normal (CN) to mild cognitive impairment (MCI).This group shows poor cognitive performance and a high prevalence of amyloid β positivity.NGN-based diagnosis of MCI predicts cognitive progression on follow-up.Results indicate that NGN improve the detection of objective cognitive impairment.NGN can inform biomarker use, therapy indication, and clinical trial design.
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