ArticleFrontiers in cellular and infection microbiology2025
Silver multilayer coating on orthopedic implant material of different alloys and surfaces significantly reduces bacterial colonization.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Porous Ti-6Al-4V Architectures in Load-Bearing Orthopedic Reconstruction: A Critical Narrative Review of the Translational Gap Across Microstructure, Fatigue, Surface Function, and Clinical Failure Modes.Materials (Basel, Switzerland) · 2026Review
- Integrating silver nanomaterials in wound healing: from physicochemical properties to clinical translation.Journal of nanobiotechnology · 2026Review
- Biofilm Formation Patterns ofAntibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Prosthetic joint infections (PJI) affect 1-3% of prosthetic joint replacements, frequently linked to biofilm formation on implant surfaces. PJIs account for 13.0-31.3% of all revision surgeries. As treatment is not always successful, prevention remains critical. Currently, silver based antimicrobial coatings are justified in select high-risk arthroplasty cases, restricted to metal surfaces. An antibacterial silver multilayer coating (SML) has been developed for implant materials: titanium alloy (Ti) and cobalt-chromium-molybdenum alloy (CoCr), often used in hip or knee prostheses. The SML coating is intended for revision implants, which are often required due to infection related implant failure. This study investigates the antibacterial performance of the SML coating across different surfaces and implant materials, using multiple bacterial strains not previously investigated to this extent. Methods: Antibacterial efficacy of the SML coating was assessed by quantifying colony forming units (CFU) reduction on Ti6Al4V and Co28Cr6M discs with three different surfaces (polished and two grades of corundum blasted (CB)). Results: Across all materials and strains, the SML coating achieved >99.2% and >0.9-4.0 CFU log Discussion and conclusion: These findings demonstrate a thorough and broad-spectrum antibacterial activity of the SML coating across diverse implant materials and surface textures. Future studies will focus on testing clinical PJI isolates in both
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