ArticleFrontiers in cellular and infection microbiology2025
Elevated DUOX2 levels correlate with necrotizing enterocolitis development.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Changes in neonatal inpatient resource utilization and cost drivers under payment reform: a five-year retrospective real-world data study.Frontiers in pediatrics · 2026Article
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8 authors.
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Abstract
Background: Neonatal necrotizing enterocolitis (NEC) is a life-threatening intestinal disease primarily affecting preterm infants. Although the exact pathophysiology remains unclear, immune responses and redox reactions play crucial roles in its development. Methods: We identified Dual Oxidase 2 (DUOX2) as a significantly upregulated gene in the intestinal tissues of NEC patients. Subsequent analyses included Gene Ontology (GO) enrichment and immune infiltration profiling related to DUOX2. Using a nested case-control design, we then evaluated the clinical relevance of serum DUOX2 protein levels in preterm infants with NEC (gestational age <32 weeks). Results: DUOX2 was significantly highly expressed in NEC intestinal tissues, with an AUC value of 0.844 (0.599-1.000) predicting the occurrence of NEC. GO enrichment analysis revealed that the differentially expressed genes (DEGs) between the NEC and control groups mainly affect redox reactions, including reactive oxygen species (ROS) and superoxide. Immunoinfiltration analysis revealed a positive correlation between DUOX2 expression and plasma cells (R=0.69, Conclusion: This study demonstrates a significant association between elevated DUOX2 expression and the development of NEC in preterm infants.
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