ArticleFrontiers in aging neuroscience2025
Primitive reflexes as behavioral biomarkers of cognitive aging: associations with physical activity and resilience-a pilot study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Intra- and Inter-Rater Reliability of Primitive Reflex Assessments in Youth Football Athletes.Journal of functional morphology and kinesiology · 2026Article
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6 authors.
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Abstract
Introduction: Primitive reflexes (PRs) are brainstem-mediated automatic responses that typically disappear in early life, but may reappear in older age, which may be associated with neurodegenerative processes. But the presence of PRs in cognitively healthy adults has not yet been sufficiently explored. The relationship between PRs and cognitive functioning (COG) may be influenced by modifiable factors such as physical activity (PA) and psychological resilience. This cross-sectional observational pilot study aimed to investigate the mediating and moderating role of physical activity and resilience in the association between primitive reflexes and cognitive functioning in older adults. Methods: A total of 30 older adults (mean age 73.4 ± 6.9 years; 80% female) living in residential care facilities were assessed. PRs were evaluated using standardized neurological protocols, COG was measured with the Mini-Mental State Examination, PA with the Global Physical Activity Questionnaire, and resilience with the Connor-Davidson Resilience Scale. Moderation and mediation models were tested using Hayes' PROCESS macro, controlling for age and BMI. Results: A higher number of primitive reflexes was strongly associated with lower cognitive functioning [COG ( Discussion: These findings highlight primitive reflexes as potential behavioral biomarkers of cognitive aging, and underscore the importance of physical activity as a protective factor that may buffer against neurocognitive decline.
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