ArticleCaspian journal of internal medicine2025
Association between vitamin D levels and urinary tract infections.
Article in Caspian journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Nutritional bioactives for preventing recurrent urinary tract infections in children: microbiome-mediated mechanisms and clinical implications.Frontiers in nutrition · 2026Review
- Vitamin D receptor polymorphisms as predictors of pediatric infectious disease prevalence and outcome: an overview of available evidence.Frontiers in immunology · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Urinary tract infections (UTIs) are among the most prevalent infectious conditions, particularly in children. Vitamin D deficiency has been implicated in various infections, including UTIs. This study aimed to evaluate the association between serum vitamin D levels and UTIs in children at Amir Kola Children's Hospital. Methods: This case-control study was conducted on 120 children, aged 2-18 years, diagnosed with UTIs and referred to Amir Kola Children's Hospital, Babol, Iran. Participants were divided into two groups: 60 UTI cases and 60 healthy controls. Peripheral blood samples were collected for vitamin D analysis, measured via ELISA assay. Statistical analysis was performed using SPSS Version 26. Results: The mean serum vitamin D level was 17.70±8.35 ng/mL in the case group and 37.91±12.18 ng/mL in the control group, revealing a significant reduction in vitamin D levels among UTI patients (P<0.001). Additionally, pyelonephritis was associated with severe vitamin D deficiency (P=0.02). Female children aged 3-5 years exhibited a higher risk of vitamin D deficiency, although age and sex did not significantly influence vitamin D levels overall. Vitamin D status was not correlated with hospitalization duration. Conclusion: Given its immunoprotective role, vitamin D screening and supplementation may serve as a preventive strategy against UTIs and contribute to improved clinical outcomes in affected children.
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