Evidence map›Paper›PMID 41383779›Full record

ArticlebioRxiv : the preprint server for biology2025

Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism.

Hye Kyung Lee, Maxim Pyatkov, Oksana Gavrilova, Naili Liu, Tamar Demby, Bingtian Ye, Priscilla A Furth, Lothar Hennighausen, David J Waxman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hye Kyung LeeSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Maxim PyatkovDepartment of Biology and Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA.
Oksana GavrilovaMouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Naili LiuMouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Tamar DembyMouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Bingtian YeDepartment of Biology and Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA.
Priscilla A FurthSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Lothar HennighausenSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
David J WaxmanDepartment of Biology and Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA.ORCID 0000-0001-7982-9206

Funding

Growth Hormone Regulation of Sex Differences in Liver MetabolismR01DK121998 · NIDDK · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WAXMAN, DAVID J · 2019 to 2023
$2.5M
NIDDK NIH HHS R01 DK121998
6 · The paper itself

Abstract

Growth hormone (GH) signaling through STAT5B is a central regulator of hepatic metabolism, yet the functional consequences of disease-associated STAT5B variants remain poorly understood. Here, we analyzed mice carrying STAT5B

Identifiers

PMID41383779
PMCPMC12694592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.