Evidence map›Paper›PMID 41383763›Full record

ArticlebioRxiv : the preprint server for biology2025

Intrinsic mechanotransduction during apical constriction licenses lineage competence in pluripotent stem cells.

Mehdi Seif Hamouda, Celine Labouesse, George W Wylde, Daniel Yamamoto, Yekaterina A Miroshnikova, Srinjan Basu, Clare M Waterman, Kevin J Chalut

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mehdi Seif HamoudaCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 20894 Bethesda, MD, USA.ORCID 0000-0003-2903-1890
Celine LabouesseCambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0002-9791-898X
George W WyldeCambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.
Daniel YamamotoCambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0003-4167-6456
Yekaterina A MiroshnikovaMax Planck Research Group on Biophysical Regulation of Cell State Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.ORCID 0000-0001-9771-4963
Srinjan BasuCambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0002-1080-979X
Clare M WatermanCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, 20894 Bethesda, MD, USA.ORCID 0000-0001-6142-6775
Kevin J ChalutCambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.ORCID 0000-0001-6200-9690

Funding

Wellcome Trust
6 · The paper itself

Abstract

To acquire the capacity for multi-lineage differentiation, pluripotent stem cells must undergo a transition from naïve pluripotency to lineage competency. This transition requires epithelialization and changes in nuclear architecture. We sought to determine whether the cell and tissue mechanics intrinsic to epithelialization drive pluripotency progression and subsequent lineage commitment to neuroectodermal fate. We demonstrate that naïve mouse embryonic stem cells (mESCs) undergoing early differentiation

Identifiers

PMID41383763
PMCPMC12694579

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.