ArticleFrontiers in microbiology2025
Evaluation of resistance modulation in MDR
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Multidrug-resistant urinary tract pathogens, primarily Methods: Clinical isolates were obtained from patients with urinary tract infections and their antibiotic susceptibility profiles were determined. The PEONE was prepared using ultrasonic emulsification and characterized, revealing a droplet size of 190.21 ± 0.5 nm and a polydispersity index (PDI) of 0.15 ± 0.021. Antibacterial activity was assessed by determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Membrane integrity was evaluated using DNA and protein leakage assays, and bacterial killing over time was measured with time-kill kinetics. Furthermore, molecular docking and 100 ns molecular dynamic simulations were performed against β-lactamase enzymes (PDB: 4EXY from Results: The bacterial isolates were resistant to Levofloxacin, Penicillin G, Ceftazidime, and amoxicillin-clavulanic acid (AMC). PEONE demonstrated potent antibacterial activity, with an MIC of 0.1% v/v and an MBC of 0.14% v/v. DNA and protein leakage increased significantly ( Discussion: The findings indicate that PEONE is effective at inhibiting and killing MDR
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.