Evidence map›Paper›PMID 41383717›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Toxicity evaluation of laser-synthesized pro-angiogenic carbon monoxide-rich gold nanoparticles

Thais Braga Gomes Araujo, Guilherme Conceição Concas, Mariana Gisbert, Gabriel de Farias Araujo, Leonardo da Cunha Boldrini Pereira, Lorena Gonçalves Henriques Corrêa Maduro, Lorena Oliveira Souza Soares, Sidney Fernandes Sales Junior, Davi Pinheiro Cunha, Fábio Veríssimo Correia and 7 more

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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Thais Braga Gomes Araujo *Postgraduate Program in Public Health and the Environment, National School of Public Health, Rio de Janeiro, Rio de Janeiro, Brazil.
Guilherme Conceição Concas *Laboratory of Laser Synthesis and Characterization of Nanomaterials, Department of Physics, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Mariana GisbertLaboratory of Laser Synthesis and Characterization of Nanomaterials, Department of Physics, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Gabriel de Farias AraujoPostgraduate Program in Public Health and the Environment, National School of Public Health, Rio de Janeiro, Rio de Janeiro, Brazil.
Leonardo da Cunha Boldrini PereiraDivision of Metrology in Biology (Dibio), Postgraduate Program in Translational Biomedicine, Postgraduate Program in Biotechnology, National Institute of Metrology, Quality and Technology (Inmetro), Xerém, Directorate of Applied Metrology for Life Sciences - Directorate of Scientific and Technological Metrology (Dimci), Duque de Caxias, Rio de Janeiro, Brazil.
Lorena Gonçalves Henriques Corrêa MaduroDivision of Metrology in Biology (Dibio), Postgraduate Program in Biotechnology, National Institute of Metrology, Quality and Technology (Inmetro), Xerém, Directorate of Scientific and Technological Metrology (Dimci), Duque de Caxias, Rio de Janeiro, Brazil.
Lorena Oliveira Souza SoaresPostgraduate Program in Public Health and the Environment, National School of Public Health, Rio de Janeiro, Rio de Janeiro, Brazil.
Sidney Fernandes Sales JuniorPostgraduate Program in Public Health and the Environment, National School of Public Health, Rio de Janeiro, Rio de Janeiro, Brazil.
Davi Pinheiro CunhaLaboratory for Environmental Health Assessment and Promotion, Oswaldo Cruz Institute, Rio de Janeiro, Rio de Janeiro, Brazil.
Fábio Veríssimo CorreiaPostgraduate Program in Public Health and the Environment, National School of Public Health, Rio de Janeiro, Rio de Janeiro, Brazil.
Anna LaurenzanaDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Cecilia AnceschiDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Elena FredianiDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Anastasia ChillàDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Francesca MargheriDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Tommaso Del RossoLaboratory of Laser Synthesis and Characterization of Nanomaterials, Department of Physics, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Enrico Mendes SaggioroPostgraduate Program in Public Health and the Environment, National School of Public Health, Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The safety profile of gold nanoparticles remains a concern and depends on dose, size, surface chemistry and charge. This study evaluated through Methods: COR-AuNPs were synthesized by pulsed laser driven CO Results: The PF127 stabilized COR-AuNPs are stable in the zebrafish aquarium water for 6 weeks and showed no precipitation in the culture media. A strong pro-angiogenic activity was observed for ECFCs exposed to the COR-AuNPs at a minimal concentration of 5 × 10 Conclusion: COR-AuNPs enhance capillary morphogenesis in ECFCs, with minimal cytotoxicity, oxidative stress, and genotoxicity at sublethal concentration, supporting their safety for potential applications in regenerative therapies.

Indexed as

angiogenesiscarbon monoxide-rich gold nanoparticlesECFCnanotoxicologyzebrafish

Identifiers

PMID41383717
PMCPMC12689510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.