Evidence map›Paper›PMID 41383619›Full record

ReviewFrontiers in immunology2025

Transcription factor c-Maf: a checkpoint that programs autoimmunity.

Na Liu, Jin Zhang, Pingping Wang, Shuyu Jin, Chunjuan Yang, Xinyi Yan, Jing Xu, Hui Wang, Wenchang Sun, Donghua Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na Liu *Center of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Jin Zhang *Department of Rheumatology, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Pingping Wang *Department of Gynecology and Obstetrics, Weifang Maternal and Child Health Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Shuyu Jin *School of Pharmacy, Shandong Second Medical University, Weifang, Shandong, China.
Chunjuan YangCenter of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Xinyi YanCenter of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Jing XuDepartment of Gynecology, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Hui WangCenter of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Wenchang SunCenter of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Donghua XuCenter of Medical Research, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor c-Maf, a member of the Maf family characterized by its basic domain and b-Zip DNA-binding motif, is a pivotal regulator of immune cells development and function. It governs immune cells growth, differentiation, function, and immune responses. This review explores the mechanistic role of c-Maf and its associated signaling networks in modulating autoimmunity and inflammation. We highlight its dual function as an immune checkpoint that suppresses pathological inflammation while promoting protective immunity, underscoring its therapeutic potential in autoimmune diseases.

Indexed as

Autoimmune DiseasesAutoimmunityProto-Oncogene Proteins c-mafAnimalsHumansInflammationSignal TransductionProto-Oncogene Proteins c-mafautoimmune diseasesautoimmunityc-Mafimmune checkpointinflammation

Identifiers

PMID41383619
PMCPMC12689506

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.