ReviewFood science & nutrition2025
Antioxidant Potential of Polyphenolic Compounds, Sources, Extraction, Purification and Characterization Techniques: A Focused Review.
Review in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Improving the cryo-resistance of Egyptian buffalo semen via chlorogenic acid and rutin supplementation: molecular docking, antioxidant, and anti-apoptotic pathways.BMC veterinary research · 2026Article
- Thermochemical Valorization of Silkworm Feeding Waste: Chemical Characterization and Biological Activities of the Pyrolysis-Derived Liquid Fraction.Antioxidants (Basel, Switzerland) · 2026Article
- Bioassay-Guided Evaluation and LC-MS/MS Characterization of FiveMolecules (Basel, Switzerland) · 2026Article
- Cardioprotective Potential of Grape-Derived Polyphenols in Cancer Therapy-Related Cardiotoxicity.International journal of molecular sciences · 2026Review
- Modulation of oxidative stress and angiogenic pathways by natural compounds in experimental preeclampsia: A narrative review focusing on MDA, sFlt-1, and PlGF.Turkish journal of obstetrics and gynecology · 2026Article
- Hormetic Antioxidant Effects ofInternational journal of molecular sciences · 2026Article
- Route-dependent efficacy of wild mint (Mentha longifolia) extract supplementation in heat-stressed broilers: physiological, intestinal and productive responses.Poultry science · 2026Article
- Optimized Ultrasound-Assisted Extraction Enhances the Recovery of Anti-Collagenase Phytochemicals fromPlants (Basel, Switzerland) · 2026Article
- The Therapeutic Architecture of Chlorogenic Acids: Molecular Mechanisms in Chronic Disease Prevention.Nutrients · 2026Review
- Anticancer Properties of Selected Wood-Inhabiting Fungi.Nutrients · 2026Review
- Valorization of Cocoa Pod Husk Through Integrated Drying and Probe Ultrasound-Assisted Extraction: Effects on Phenolic Composition, and Antioxidant and Cellular Anti-Inflammatory Activities.Foods (Basel, Switzerland) · 2026Article
- Development of a Sustainable Natural Brown Colorant from Date Seed Waste: Taguchi Optimization and Storage Stability.Foods (Basel, Switzerland) · 2026Article
- Review
- Integrated Assessment of Bioactive Properties of NinePlants (Basel, Switzerland) · 2026Article
- Effects ofMolecules (Basel, Switzerland) · 2026Article
- Integrated Phytochemical and Pharmacological Insights intoPlants (Basel, Switzerland) · 2026Review
- Nutritional assessment, multi-platform phytochemical profiling, and biological activities of Centaurea calcitrapa L. based on GC-MS and HPLC analysis.Scientific reports · 2026Article
- Unlocking Potential ofGels (Basel, Switzerland) · 2026Article
- The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota and Type 2 Diabetes.International journal of molecular sciences · 2026Review
- Phenolic Composition, Antioxidant Activity and Caffeine as Chemical Markers for Differentiating PanamanianMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenolic compounds, which are abundant phenolic metabolites in plants, have attracted significant attention because of their diverse biological activities and robust antioxidant properties. This review uniquely describes the extraction characterization, and application pipeline for polyphenols, emphasizing their mechanistic antioxidant actions and translational challenges. Between 1979 and 2025, approximately 141 relevant studies were critically examined, covering the sources, extraction and purification methods, structural diversity, and biological implications of polyphenols. Special attention is given to bioavailability, dose-dependent effects, and subclass-specific activities. Various extraction techniques, including solvent extraction, supercritical fluid extraction, and solid-phase extraction, have been evaluated along with advanced characterization approaches such as spectroscopy and chromatography. The antioxidant mechanisms of polyphenols, ranging from radical scavenging and metal chelation to modulation of signaling pathways, are described, along with their broad applications in nutrition, medicine, and industry. This focused synthesis highlights not only the current state of knowledge, but also identifies key research gaps in clinical validation, formulation strategies, and industrial adoption, providing a forward-looking perspective for future polyphenol research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.