Evidence map›Paper›PMID 41383576›Full record

ArticleFrontiers in molecular neuroscience2025

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer.

Valentina A Penniyaynen, Dmitriy M Samosvat, Vera B Plakhova, Svetlana A Podzorova, Anna V Berintseva, Irina P Butkevich, Viktor A Mikhailenko, Georgy G Zegrya, Ke Ma, Ilya V Dukhovlinov and 2 more

Abstract read
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In one paragraph

Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Valentina A PenniyaynenLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Dmitriy M SamosvatIoffe Institute, Russian Academy of Sciences, Saint Petersburg, Russia.
Vera B PlakhovaLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Svetlana A PodzorovaLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Anna V BerintsevaLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Irina P ButkevichLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Viktor A MikhailenkoLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Georgy G ZegryaLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Ke MaDepartment of Pain Management, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ilya V DukhovlinovATG Service Gene LLC, Saint Petersburg, Russia.
Boris V KrylovLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Ilya V RogachevskiiLaboratory of Physiology of Excitable Membranes, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A potential analgesic medicinal substance has been discovered, the ouabain-Ca

Indexed as

analgesicsdockingformalin testK-ATPase signaling functionNaNav1.8 channelnociceptionorganotypic tissue culture methodouabain–Ca2+ chelate complex

Identifiers

PMID41383576
PMCPMC12689507

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.